Cambridge Eye Trust

The Cambridge Eye Trust
A Registered Charity
(Charity No 265140)
The Green
Cambs PE28 9NB

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Glaucoma Research

Professor Keith Martin has research programmes in the on-site Cambridge Centre for Brain Repair. Projects include numerous studies on the mechanisms of retinal ganglion cell death in glaucoma and the development of new treatment approaches. The senior post-docs, research fellows and PhD students in the lab are also engaged in stem cell research to protect and repair the damaged retina. As well as such pre-clinical work, there are a number of clinical research projects underway, including the UK Glaucoma Treatment Study and investigations into the effects of cyclodiode laser treatment, selective laser trabeculoplasty and trabeculectomy on glaucoma progression. Professor Martin is Cambridge University's first Professor of Ophthalmology and recognised as a global leader in glaucoma research.

Stem cells derived from human retinal RGC01 RGC02
A Muller (glial) stem cell (green) derived from human retina and transplanted into the vitreous of a rat with glaucoma differentiates to become a neuronal like cell with connections to other cells File name: RGC01 and RGC02 CF
Caption: High magnification view of the structure of a retinal ganglion cell expressing green fluorescent protein (green) in a whole-mount preparation of a mouse retina. This image allows us to see the full dendritic structure of this cell. The rest of the retinal ganglion cells in the background are stained for betaIII-tubulin expression (red) which allows us to see their fine processes and axons (which bundle together to enter the optic nerve and connect the eye to the brain).

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Rupert BourneProf Rupert Bourne's group, based mainly at the Vision & Eye Research Unit of Anglia Ruskin University and Hinchingbrooke Hospital, specialises in large, mainly international, epidemiological studies of eye disease and specifically in glaucoma and particularly angle closure. He coordinates the Vision Loss Expert Group of the Global Burden of Disease Study, a collaboration between many international centres and the WHO (funded by the Bill & Melinda Gates Foundation).

e co-manages the CHANGES scheme (Community & Hospital Allied network Glaucoma Evaluation Scheme) that involves optometrists in shared care of referred patients and those with ocular hypertension. This has led to the Health Innovation and Education Cluster (HIEC) Glaucoma theme project which is looking at shared care nationally for glaucoma. The Huntingdon Glaucoma Diagnostic and Research Centre is currently running 9 NHS clinical research trials, that involve novel pharmaceutical agents, medical devices and laser procedures for the treatment of glaucoma. Prof Bourne is the West Anglia lead for the Ophthalmology Specialty Group, one of the specialty groups of the Comprehensive Local Research Network.

- View Rupert Bourne Publications